LRP8 (Low-density lipoprotein receptor-related protein 8 gene)
About LRP8
Several genes are involved in the central nervous system including the LRP8 gene and the GSR gene. LRP8 stands for "Low-density lipoprotein receptor-related protein 8" and plays an important role in nerve cell connections, memory and spatial awareness in racing pigeons at the level of the hippocampus. In most pigeon species including rock pigeons, we see the normal wild-type LRP8(GG). In racing pigeons, a mutation LRP8(T) was found that causes a Q to H change in the protein. We name the mutation according to the nucleotide change (G to T) and not the protein change (Q to H). Racing pigeons with the LRP8(T) mutation would have a strong advantage with better navigation, memory and spatial awareness. For breeding pigeons, the LRP8(TT) double mutation will be very interesting.
Suitable samples
Feathers
- One set of 4-5 freshly plucked breast feathers or 2-3 tail or wing feathers
- Fallen moulting feathers, down feathers and blood feathers should be avoided. These sometimes contain insufficient DNA or can cause damage to the feather follicle when pulled out.
- Blood feathers are the new feathers that can be recognised by the blue sleeve at the base of the plume.
- To avoid contamination, the shaft (the end of the feather that comes out of the bird's skin) must not be touched with the hands
Blood sample
- Small amounts (capillary tube) are sufficient for accurate analysis
Cheek swab of a nestling
- A gentle way to collect DNA from young birds
- Caution: avoid mixing with food or food waste
Results
- Processing time 2-3 working days
- You will receive an email when your results and certificate are available on your personal portal