LDHA (Lactate dehydrogenase gene type A)

Lactate dehydrogenase, an enzyme encoded by the LDHA gene, plays a known role in our physical and mental health. The point mutation on the LDHA gene is located on an intron. Such a change in an intron can affect how often the gene is used to make the protein. This is called gene expression. However, when looking at the point mutation in the LDHA gene in pigeons, it is not yet clear how this mutation, based solely on the altered enzyme activity, affects their flight performance. There may be other, as yet unknown mutations that are inherited along with the LDHA^A allele that also have an impact on flight performance. 

Scientific research undeniably shows that selection based on the LDHA^A allele in racing pigeons can improve the genetic quality of their performance. In short, by selective breeding based on this allele, we can optimise the performance of racing pigeons. Some studies with a limited sample in a standard Belgian group of racing pigeons show that about 3.74% have the LDHA^AA genotype. In addition, some 22.42% have the LDHA^AG genotype (= LDHA^AB genotype). These percentages are probably even on the high side. However, in the pigeons that perform best, the LDHA^A allele is more common.